Statistical Modeling of Physical Characteristics of Fast Disintegrating Glipizide Tablets Using Polymeric Properties

The purpose of present study was modeling of statistical relationship between physical attributes of fast disintegrating glipizide (GPZ) tablets and physicochemical properties of polymers used therein. Polymers are type of excipients used for achieving the drug delivery to the desired site in safe and effective way. In present research, various physicochemical properties were calculated for three different polymers and subsequently correlated with physical characteristics of GPZ tablets. This resulted into selection of a statistical model with best correlation and minimal error out of several models developed for each characteristic of formulation. Fourier transform infrared spectroscopic studies confirmed the compatibility between GPZ and all polymers. Estimated parameters for GPZ fast disintegrating tablets such as uniformity of weight (0.32 to 0.55 %), GPZ content (98.97 to 101.34 %), hardness (4.01 to 4.32 Kg/cm 2 ) and friability (0.277 to 0.803 %) were found to be within the prescribed official standards. Also, disintegration time (DT) for tablets from all batches (28.00 to 71.33 sec) indicated faster disintegration. Correlation coefficient (r 2 ) of mathematical models developed for friability (r 2 =+0.9657), hardness (r 2 =+0.9450) and DT (r 2 =+0.9292) specified good correlation with significant effect (F-test) of all selected polymeric properties on physical characteristics of tablets. Therefore, such models could be able to quantitatively predict the polymeric properties that should be highly considered while selecting polymer/s in formulation for required physical characteristics. Subsequently, developed models may also assist in deciding composition of formulation without its actual formulation with saving of material, time and cost of industry.